个人简介
胡志伟，男，博士，实验师，2016年在东北林业大学获理学博士学位，攻读博士期间赴美国佛罗里达大学药学院进行联合培养学习，长期致力于天然产物分析和利用方面的研究工作，并有丰富的仪器分析的经验；已在Nature Communications，Journal of Agricultural and Food Chemistry，Nano Research，Pharmacology & Therapeutics，Chemico-Biological Interactions和色谱等国内外期刊发表研究论文29篇。
联系电话：14757790212
电子邮箱：zhiwei.hu@wzu.edu.cn
主要研究方向
天然产物分析和利用、药物代谢动力学研究、仪器分析技术。
发表论文
[1] Xue Liu#, Mengyuan Jin#, Ping Yu#, Nan Hou, Yun Yang, Shun Wang, Zhiwei Hu*, Juan Wang*, Huile Jin*. PdPtNi hollow nanocages for boosting alkaline hydrogen oxidization/evolution reactions. Nano Research. 2025, 18(12): 94907830.
[2] Chenxue Song#, Ziming Wang#, Meijia Yan, Zijia Wang, Qiang Zhang, Yonghong Jiang, Tao Yu, Jian Zheng, Zhisong Cao, Yang Wang* Zhiwei Hu*. Comprehensive metabolite profiling of 10-methoxycamptothecin in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Asian Natural Products Research. 2025, 15:1-12.
[3]Zhiwei Hu#, Meijia Yan#, Chenxue Song#, Muneo Sato, Shiwen Su, Sue Lin, Junliang Li, Huixi Zou, Zheng Tang*, Masami Yokota Hirai*, Xiufeng Yan*. An Integrated Approach for the Comprehensive Characterization of Metabolites in Broccoli (Brassica oleracea var. Italica) by Liquid Chromatography High-Resolution Tandem Mass Spectrometry. Plants (Basel). 2025, 14(20):3223.
[4] Chenxue Song#, Meijia Yan#, Sue Lin, Junliang Li, Huixi Zou, Zhiwei Hu*, Xiufeng Yan*. Dual-Ionization SPME-GC-HRMS Metabolomic Profiling of Broccoli Volatiles for the Construction of a Broccoli Metabolic Database. Molecules. 2025, 30(18):3781.
[5] Xinxin Liu, Qiang Zhang, Zijia Wang, Yonghong Jiang, Yang Wang, Huixi Zou, Xiufeng Yan, Zhiwei Hu*and Ziming Wang*. A UPLC-ESI/MS/MS Method for the Determination of Betulinic Acid and Its Application to the Pharmacokinetic Study in Rat Plasma. Pharmaceutical Chemistry Journal. 2025, 59(3):361-367.
[6] Ziming Wang, Junjie Chi, Zhiwei Hu*, Changmin Shao*. Versatile ordered porous scaffold blooming from microfluidics. Applied Materials Today. 2024, 37, 102156.
[7] Dongsheng Zhao#, Zhiwei Hu#, Lingli Dong, Xiaojie Wan, Shengqin Wang, Nan Li, Yao Wang, Shuming Li, Huixi Zou, Xiufeng Yan. A Type III Polyketide Synthase (SfuPKS1) Isolated from the Edible Seaweed Sargassum fusiforme Exhibits Broad Substrate and Catalysis Specificity. Journal of Agricultural and Food Chemistry. 2021, 69(48):14643-14649.
[8] Ziming Wang, Yu Wang, Tao Yu, Zhiwei Hu*, Yang Wang*. An LC-ESI/MS/MS method for the determination of lupeol via precolumn derivatization and its application to pharmacokinetic studies in rat plasma. Biomedical Chromatography. 2021, 35:e5005
[9] Zhuangzhi Sun*, Lu Yang, Sicheng Liu, Jintao Zhao, Zhiwei Hu* and Wenlong Song*. A Green Triboelectric Nano-Generator Composite of Degradable Cellulose, Piezoelectric Polymers of PVDF/PA6, and Nanoparticles of BaTiO3. Sensors (Basel). 2020, 20(2):506.
[10]Zhiwei Hu, Ziming Wang, Shaman Luo, Margaret O. James, Yang Wang. Phase II metabolism of betulin by rat and human UDP-glucuronosyltransferases and sulfotransferases. Chemico-Biological Interactions, 2019, 302, 190-195.
[11]Zhiwei Hu#, Ziming Wang, Yong Liu, Yan Wu, Xuejiao Han, Jian Zheng, Xiufeng Yan, Yang Wang*. Metabolite Profile of Salidroside in Rats by Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry and High-Performance Liquid Chromatography Coupled with Quadrupole-Linear Ion Trap Mass Spectrometry. Journal of Agricultural and Food Chemistry, 2015, 63(41):8999-9005.
[12] Zhiwei Hu#, Na Guo#, Ziming Wang, Yong Liu, Yu Wang, Weimin Ding, Dehui Zhang, Yang Wang*, Xiufeng Yan*, Development and validation of an LC-ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma, Journal of Chromatography B, 2013, 939, 38-44.
[13] Na Guo#, Zhiwei Hu#, Xiaoxu Fan, Jian Zheng, Dehui Zhang, Tao Xu, Tao Yu, Yang Wang* and Haiying Li*. Simultaneous Determination of Salidroside and Its Aglycone Metabolite p-Tyrosol in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Molecules, 2012, 17, 4733-4754.
[14] 胡志伟#, 郭 娜#, 王 洋*. 超高效液相色谱法测定大鼠血浆中红景天苷含量. 营养学报, 2012, 4:278-281.
[15] DongSheng Zhao#, Shengqin Wang#, YiCheng Xu#, Yu-Ting Chen, Muhammad Ahsan Farooq, Sue Lin, Peng Cao, Junliang Li, Zhiwei Hu, Nan Li, Matteo Scarsini, Chuanling Si, ShuMing Li, Xiufeng Yan, Qiuying Pang*, Chris Bowler*, Huixi Zou*. Tryptophanol enhances nitrogen assimilation in marine diatoms. Nature Communications. 2026, doi: 10.1038/s41467-026-71191-8.
[16] Shuo Wang, Dexi Shi, Lu Liu, Yike Wang, Ziyi Lin, Fengming Huang, Zhiwei Hu, XiuFeng Yan*, Sue Lin*. Methyl Jasmonate Enhances HXK2-Mediated Indolic Glucosinolate Biosynthesis in Broccoli. Journal of Agricultural and Food Chemistry 2025, 73(50):32379-32394.
[17] Jiamin Xu, Yicheng Xu, Chenxi Cheng, Dongsheng Zhao, Zhiwei Hu, Shuming Li, Salah Fatouh Abou-Elwafa, Xiufeng Yan, Huixi Zou* Nan Li*. SfuPKS2, a novel type III polyketide synthase from Sargassum fusiforme, shows highly substrate specificity. Journal of Applied Phycology. 2024, 36: 2359-2368
[18] Qiang Zhang, Ping Zou, Meixuan Zhu, Dan Sui, Shaoming Wang, Zhiwei Hu, Yang Wang, Lijia Jing, Jian Zheng. Synthesis and biological activity assay of novel camptothecin-peptidic conjugates based on PEPT1. Bioorganic & Medicinal Chemistry Letters. 2023, 96:129502.
[19] Meijia Yan#, Chenxue Song#, Shiwen Su, Junliang Li, Zhiwei Hu, Sue Lin, Huixi Zou, Zheng Tang* and Xiufeng Yan*. Quantification and Diversity Analyses of Glucosinolates in 191 Broccoli Genotypes Highlight Valuable Genetic Resources for Molecular Breeding. Agronomy 2023, 13, 2928.
[20] Haiyan Lin#, Jiayi Sun#, Zhiwei Hu, Chenxi Cheng, Sue Lin, Huixi Zou*, Xiufeng Yan*. Variation in Glucosinolate Accumulation among Different Sprout and Seedling Stages of Broccoli (Brassica oleracea var. italica). Plants (Basel). 2022, 11(12):1563.
[21] Ziming Wang, Changmin Shao, Zhiwei Hu, Jian Zheng, Qiang Zhang, Xiaohan Kou, Zijia Wang, Tao Yu, Zhisong Cao*, Yang Wang*. The development and validation of an LC-MS/MS method for the quantification of CZ112, a prodrug of 9-Nitrocamptothecin in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2020, 179:112963.
[22] Weimin Ding, Xing Jin, Boyu Ma, Xiaobing Wang, Chenmei Lou, Jian Zheng, Zhiwei Hu, Lijia Jing & Yang Wang. Determination of Prussian Blue Nanoparticles in Rat Tissue in the Presence of Endogenous Iron Interferences by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). Analytical Letters. 2020, 53(18), 2935–2948.
[23] Marci G. Smeltz, Zhiwei Hu, Guo Zhong, Stephan C. Jahn, Laura Rowland-Faux, Lloyd P. Horne. Peter W. Stacpoole. Margaret O. James. Mitochondrial Glutathione Transferase Zeta 1 is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver. Chemical Research in Toxicology. 2019;32(10):2042-2052.
[24] Stephan C. Jahn, Marci G. Smeltz, Zhiwei Hu, Laura Rowland-Faux, Guo Zhong, Ryan J. Lorenzo, Katherine V. Cisneros, Peter W. Stacpoole, Margaret O. James, Regulation of Dichloroacetate Biotransformation in Rat Liver and Extrahepatic Tissues by GSTZ1 Expression and Chloride Concentration. Biochemical Pharmacology. 2018, 152, 236-243.
[25] Margaret O. James, Stephan C. Jahn, Guo Zhong, Marci G. Smeltz, Zhiwei Hu, Peter W. Stacpoole. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacology & Therapeutics. 2017, 170, 166-180.
[26] Na Guo#, Weimin Ding, Yu Wang, Zhiwei Hu, Ziming Wang, Yang Wang*. An LC–MS/MS method for the determination of salidroside and its metabolite p-tyrosol in rat liver tissues. Pharmaceutical biology. 2014, 52(5): 637-645.
[27] 王子铭, 胡志伟, 张生, 丁为民, 阎秀峰, 王洋*. 超高效液相色谱法测定大鼠粪便中的桦木醇. 中成药, 2014, 9:2002-2004.
[28] 刘永, 唐英斐, 宋金凤, 胡志伟. 固相萃取-液相色谱-串联质谱法测定蔬菜中4种有机磷农药及其代谢产物. 色谱. 2014, 32(02):139-144.
[29] Jian Zheng#, Rui Zhang, Changmin Shao, Zhiwei Hu, Di Wang, Tao Yu, Xiufeng Yan, Yang Wang*. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. Journal of Chromatography B. 2012, 903, 81-87.
科研项目
[1] 横向项目：南麂海滨浮标、渔寮生态浮标升级改造，2024.09-2026.06，211万，主持
[2] 温州市基础性科研项目：茉莉酸甲酯诱导的新型双吲哚芥子油苷的发现及其调控规律研究，2023.01-2024.12，3万，主持
[3] 省教育厅一般科研项目：抗肿瘤喜树碱衍生物CZ48代谢机制研究，2021.10 -2023.10,1万，主持
[4] 中央高校基本科研业务费专项资金项目：桦木醇在大鼠和人体外代谢酶动力学研究，2017.03-2020.02，6万，主持
[5] 国家重点研发计划“政府间国际科技创新合作”重点专项：西兰花芥子油苷代谢调控机制的解析与利用，2022.09-2025.08，300万元，参与
[6] 省自然科学基金-公益项目：以长春花毛状根为底盘合成长春花碱类抗癌药物的重要前体文多灵，2021.10-2023.10，10万，参与
[7] 中央高校基本科研业务费专项资金项目：喜树碱拟肽化衍生物的合成、评价与筛选，中央高校基本科研业务费专项资金项目2017.03-2020.02，12万，参与
承担的主要课程
现代仪器分析技术
